one tablet /day 

Indication 

osteoarthritis 

rheumatoid  arthritis 

painful inflammatory condition 

 Etodolac 600 extended release

once daily Continue 24 hrs 

proven safety over prolonged use 

Marked G.I tolerability 

Prostaglandins are made by two different 

 cyclooxygenase-1 (COX-1) 

cyclooxygenase-2 (COX-2) 

 COX-2 inhibitors are NSAIDs that selectively block the COX-2 enzyme and not the COX-1 enzyme. Blocking this enzyme impedes the production of prostaglandins by the COX-2 enzyme that often cause the pain and swelling of inflammation and other painful conditions. Because they selectively block the COX-2 enzyme and not the COX-1 enzyme

these drugs are uniquely different from traditional NSAIDs which usually block both COX-1 and COX-2 enzymes.